Something for Nothing
1Agalloco & Associates jagalloco@aol.com.
PDA Journal of Pharmaceutical Science and Technology
|April 21, 2023
Abstract:
This article reviews the evolution of performance standards for aseptic processing as defined by regulatory, pharmacopoeial, and industry activities. The increasing rigor of the expectations for sterility testing, environmental monitoring, and process simulation have made for improvements in capability for sterile manufacturing. The document explains why contemporary requirements are such that satisfying them requires a shift in operating practice from manned clean rooms to isolation technology.
Related Concept Videos
01:52Persuasion Strategies
38.8K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
38.8K
01:21Free Energy
48.3K
Free energy—abbreviated as G for the scientist Gibbs who discovered it—is a measurement of useful energy that can be extracted from a reaction to do work. It is the energy in a chemical reaction that is available after entropy is accounted for. Reactions that take in energy are considered endergonic and reactions that release energy are exergonic. Plants carry out endergonic reactions by taking in sunlight and carbon dioxide to produce glucose and oxygen. Animals, in turn, break...
48.3K
01:14Zeroth Law of Thermodynamics
5.2K
Experimentally, if object A is in equilibrium with object B, and object B is in equilibrium with object C, then object A is in equilibrium with object C. That statement of transitivity is called the "zeroth law of thermodynamics." For example, a cold metal block and a hot metal block are both placed on a metal plate at room temperature. Eventually, the cold block and the plate will be in thermal equilibrium. In addition, the hot block and the plate will be in thermal equilibrium.
5.2K
01:05An Introduction to Free Energy
8.6K
How can we compare the energy that releases from one reaction to that of another reaction? We use a measurement of free energy to quantitate these energy transfers. Scientists call this free energy Gibbs free energy (abbreviated with the letter G) after Josiah Willard Gibbs, the scientist who developed the measurement. According to the second law of thermodynamics, all energy transfers involve losing some energy in an unusable form such as heat, resulting in entropy. Gibbs free energy...
8.6K
01:30Zero-Force Member
1.5K
A truss is a framework that comprises slender members connected at their ends by joints. Trusses are widely used in engineering and architecture to stabilize and strengthen structures like bridges, roofs, and towers. Truss members are designed to carry loads through tension and compression, enabling the truss to withstand external forces.
One critical concept in truss design is the idea of zero-force members. It refers to a truss member that experiences no stress under loading conditions.
One critical concept in truss design is the idea of zero-force members. It refers to a truss member that experiences no stress under loading conditions.
1.5K
01:10First Law: Particles in One-dimensional Equilibrium
7.0K
Newton's first law of motion states that a body at rest remains at rest, or if in motion, remains in motion at constant velocity, unless acted on by a net external force. It also states that there must be a cause for any change in velocity (a change in either magnitude or direction) to occur. This cause is a net external force. For example, consider what happens to an object sliding along a rough horizontal surface. The object quickly grinds to a halt, due to the net force of friction. If...
7.0K