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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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Related Experiment Video

Updated: Aug 1, 2025

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
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Aerosol pulmonary immune engineering.

Emma R Sudduth1, Michael Trautmann-Rodriguez1, Nicole Gill1

  • 1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.

Advanced Drug Delivery Reviews
|April 26, 2023
PubMed
Summary
This summary is machine-generated.

Inhaled immunotherapies offer a promising way to treat lung diseases by directly targeting the lung

Keywords:
AsthmaBiologicsCOPDCOVID-19CancerCystic fibrosisImmune engineeringImmunotherapyParticulatesPulmonary deliverySmall molecules

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Area of Science:

  • Pulmonary immunology
  • Drug delivery systems
  • Immunoengineering

Background:

  • Aerosolized immunotherapies can modulate the lung's immune environment and cellular defenses.
  • Targeting mucosal-associated lymphoid tissue can influence systemic immune responses.

Purpose of the Study:

  • To review immunoengineering strategies for inhaled immunotherapies in pulmonary disorders.
  • To discuss formulation, delivery, and immune modification advantages of various platforms.

Main Methods:

  • Literature review of historical and novel inhaled immunotherapy approaches.
  • Analysis of small molecules, biologics, particulates, cell therapies, and vaccines.
  • Examination of formulation design and preclinical models.

Main Results:

  • Inhalable immunoengineering encompasses diverse platforms from small molecules to cell therapies.
  • Formulation design is critical for effective aerosol delivery and immune response.
  • Various platforms offer distinct advantages for desired immune modifications.

Conclusions:

  • Inhaled immunotherapies present a powerful strategy for treating inflammatory lung diseases.
  • Further research into clinical translation of these platforms is warranted.