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Extraction: Advanced Methods

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...

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Related Experiment Video

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Fizzy Extraction of Volatile Organic Compounds Combined with Atmospheric Pressure Chemical Ionization Quadrupole Mass Spectrometry

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Folic Acid Ionic-Liquids-Based Separation: Extraction and Modelling.

Alexandra Cristina Blaga¹, Elena Niculina Dragoi¹, Alexandra Tucaliuc¹

¹"Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, D. Mangeron 73, 700050 Iasi, Romania.

Molecules (Basel, Switzerland)

|April 28, 2023

Summary

This summary is machine-generated.

Ionic liquids effectively separate folic acid (vitamin B9) from solutions. This study achieved 99.56% recovery using CYPHOS IL103, overcoming a key barrier for biological production methods.

Keywords:

CYPHOS IL103 extraction ionic liquid modelling vitamin B9

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Area of Science:

Biochemical Engineering
Separation Science
Green Chemistry

Background:

Folic acid (vitamin B9) is vital for human health.
Biological production of folic acid is hindered by costly separation processes.
Ionic liquids show promise for separating organic compounds.

Purpose of the Study:

To investigate the efficacy of ionic liquids for folic acid separation.
To identify optimal conditions for vitamin B9 recovery from aqueous solutions.

Main Methods:

Evaluated 5 ionic liquids and 3 organic solvents as extraction media.
Tested folic acid separation from diluted aqueous solutions at pH 4.
Employed Artificial Neural Networks (ANNs) with Grey Wolf Optimizer (GWO) for process modeling.

Main Results:

Achieved a 99.56% separation efficiency using 120 g/L CYPHOS IL103 in heptane.
Demonstrated ionic liquids' potential for recovering vitamin B9 from fermentation broths.
Optimized conditions included specific ionic liquid concentrations and pH.

Conclusions:

Ionic liquids offer a viable and efficient method for folic acid separation.
This advancement can facilitate large-scale implementation of biological folic acid production.
The developed ANNs-GWO model accurately represents the separation process characteristics.