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Characterization of the Spectrum of Activity of IPD079Ea: A Protein Derived From Ophioglossum pendulum (Ophioglossales: Ophioglossaceae) With Activity Against Western Corn Rootworm [Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae)].

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Genetically modified DP915635 maize is agronomically and compositionally comparable to non-genetically modified

Jennifer A Anderson1, James Mickelson1, Brandon J Fast1

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Summary

Genetically modified maize DP915635, engineered for insect resistance and herbicide tolerance, showed no significant agronomic or compositional differences compared to non-GM maize. This indicates its safety and comparability to conventional varieties.

Keywords:
Zea mays L.agronomicscompositiongenetically modifiedsafety assessmentsubstantial equivalence

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Area of Science:

  • Agricultural Science
  • Biotechnology
  • Genetics

Background:

  • Genetically modified (GM) maize DP915635 expresses insecticidal IPD079Ea protein for corn rootworm control.
  • It also expresses phosphinothricin acetyltransferase (PAT) for glufosinate herbicide tolerance and phosphomannose isomerase (PMI) as a selectable marker.

Purpose of the Study:

  • To evaluate the agronomic performance and compositional equivalence of DP915635 maize compared to non-GM controls.
  • To assess the safety and comparability of GM maize for agricultural and nutritional purposes.

Main Methods:

  • Field studies across ten US and Canadian sites during the 2019 growing season.
  • Agronomic endpoints (e.g., stand count, flowering time) and detailed compositional analyses (proximate, fiber, minerals, amino acids, fatty acids, vitamins, etc.) were performed.
  • Statistical analyses included FDR-adjustment for p-values and comparison against established natural variation ranges.

Main Results:

  • No statistically significant agronomic differences were found after FDR-adjustment.
  • Minor statistically significant differences in 7 out of 79 compositional analytes were not significant after FDR-adjustment.
  • All compositional analyte values fell within the established ranges of natural variation.

Conclusions:

  • DP915635 maize is agronomically comparable to non-GM near-isoline and commercial maize.
  • Compositional analyses demonstrate that DP915635 maize is equivalent to non-GM maize varieties.
  • The study supports the safety and comparability of this GM maize trait.