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Articulation-Function-Associated Cortical Developmental Changes in Patients with Cleft Lip and Palate.
Wenjing Zhang1,2, Cui Zhao3, Liwei Sun4
1Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.
Brain Sciences
|May 16, 2023
Summary
Cleft lip and palate (CLP) patients show abnormal brain development affecting articulation. This study reveals delayed cortical development in specific brain regions, impacting speech in CLP individuals.
Area of Science:
- Neuroscience
- Developmental Biology
- Speech Pathology
Background:
- Cleft lip and palate (CLP) is a common congenital condition.
- Articulation disorders affect 40-80% of CLP patients post-surgery.
- The link between CLP-related articulation issues and cortical development is not well understood.
Purpose of the Study:
- To investigate developmental changes in cortical structures in CLP patients with articulation disorders.
- To explore the association between articulation disorders and cortical structure development in CLP.
- To compare cortical development patterns between CLP patients and healthy controls.
Main Methods:
- Structural and functional magnetic resonance imaging (MRI) was used.
- Participants included CLP adolescents and adults, and healthy controls.
- Mediation analysis was performed to assess the relationship between cortical thickness, age, and articulation function.
Main Results:
- Distinct abnormal cortical structures were observed in adolescent and adult CLP patients.
- CLP patients exhibited delayed cortical development in the left lingual gyrus, inferior temporal cortex, and right precentral cortex compared to controls.
- Left pericalcarine cortex thickness mediated the relationship between age and articulation function.
Conclusions:
- CLP patients display abnormal cortical structure development.
- This abnormal development is directly associated with their articulation disorders.
- Findings highlight the impact of craniofacial malformations on neurodevelopment and speech.
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