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Multiomics Analyses of Peripheral Artery Disease Muscle Biopsies

Ishita Jain1,2,3, Beu P Oropeza1,2,3, Ngan F Huang1,2,4,3

  • 1Department of Cardiothoracic Surgery (I.J., B.P.O., N.F.H.), Stanford University, CA.

Circulation Research
|May 25, 2023
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Editorialchronic limb-threatening ischemiagene expression profilingperipheral arterial diseaseproteomics

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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