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Updated: Jul 27, 2025

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

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Published on: October 4, 2022

Comprehensive powder flow characterization with reduced testing.

Catarina Chendo¹, João F Pinto², Maria C Paisana¹

¹R&D Analytical Development, Hovione Farmaciência S.A., 1649-038 Lisboa, Portugal.

International Journal of Pharmaceutics

|June 6, 2023

Summary

This summary is machine-generated.

This study characterizes pharmaceutical powder blends using rheological techniques to understand powder flow. The yield locus test is recommended for comprehensive flowability assessment, reducing early development testing.

Keywords:

Flowability Oral dosage forms Powder blend Rheology Ring shear cell test

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Area of Science:

Pharmaceutical Sciences
Materials Science
Chemical Engineering

Background:

Powder flow is crucial for pharmaceutical blend uniformity and tablet production.
Characterizing powder attributes and inter-component interactions is key to understanding blend behavior.

Purpose of the Study:

To characterize pharmaceutical powder blends using various rheological techniques.
To identify which rheological tests provide the most informative data on blend flowability.
To reduce the number of tests required in early pharmaceutical development phases.

Main Methods:

Evaluation of two cohesive powders: spray-dried hydroxypropyl cellulose (SD HPMC) and micronized indomethacin (IND).
Formulation of blends with common excipients: lactose monohydrate (LAC), microcrystalline cellulose (MCC), magnesium stearate (MgSt), and colloidal silica (CS).
Application of multiple rheological techniques to assess powder flow properties.

Main Results:

Powder flowability is influenced by particle size, bulk density, morphology, and lubricant interactions.
Angle of repose (AoR), compressibility percentage (CPS), and flow function coefficient (ffc) are sensitive to blend particle size.
Specific Energy (SE) and effective angle of internal friction (φe) correlate with particle morphology and lubricant interactions.

Conclusions:

The yield locus test provides comprehensive data on powder flow features, including those related to morphology and lubricant interactions.
Utilizing the yield locus test can streamline powder flow characterization, saving time and materials in early development.
Selecting appropriate rheological tests is essential for efficient and effective pharmaceutical formulation development.