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Updated: Jul 27, 2025

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
Published on: May 7, 2014
THE TEMPORAL SCHEDULE OF DNA SYNTHESIS AND CELL DIFFERENTIATION
1Department of Pathology, Kyoto Prefectural University of Medicine, Kamikyo-ku, Hirokoji, Kyoto 606, Japan.
Abstract:
The temporal schedule of DNA synthesis in cells of developing and adult mice is analysed by means of Feulgen cytofluorometry combined with tritiated thymidine autoradiography. The results obtained with cells taken from liver, esophageal epithelium and mucosae of gastrointestinal tracts seemed to conform to the hypothesis that a cell at a particular state of cytodifferentiation possesses specifically inactivated sets of late replicating genes showing a specific pattern of the temporal schedule of DNA synthesis.
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