Fabrication and Synthesis of Thiococlchicoside Loaded Matrix Type Transdermal Patch

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Materials Science

Background:

• Transdermal drug delivery offers an alternative route to oral administration, bypassing first-pass metabolism.
• Thiocolchicoside (THC) is a muscle relaxant with potential for topical application.
• Developing effective transdermal patches requires careful selection of polymers and excipients.

Purpose of the Study:

• To synthesize and fabricate matrix-type transdermal patches for Thiocolchicoside (THC).
• To enhance THC absorption via the topical route, avoiding first-pass metabolism.
• To achieve a consistent and extended duration of therapeutic activity.

Main Methods:

• Fabrication of transdermal patches using Eudragit L100, HPMC, PVP K30, propylene glycol, triethyl citrate, and Dura Tak 87-6908.
• Characterization of patches using Scanning Electron Microscopy (SEM), FTIR, DSC, and XRD.
• Evaluation of physicochemical properties including drug content, moisture uptake, and ex-vivo permeation studies using pig ear skin.

Main Results:

• FTIR confirmed the compatibility of THC with all excipients in the polymer matrix.
• DSC indicated the melting point of THC within the formulation.
• Physicochemical evaluations showed high drug content (96-98.56%) and controlled moisture uptake.
• Drug release kinetics were found to be dependent on the formulation composition.

Conclusions:

• The developed transdermal patches demonstrate potential for effective THC delivery.
• Optimized polymeric compositions and manufacturing processes are crucial for successful transdermal drug administration.
• This technology platform supports the development of novel transdermal drug delivery systems.