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Neurooncology: 2021 update.

Pieter Wesseling1,2

  • 1Department of Pathology, Amsterdam University Medical Centers, location VUmc, Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.

Free Neuropathology
|June 7, 2023
PubMed
Summary
This summary is machine-generated.

Neuro-oncological pathology discoveries in 2020 include new insights into glioma molecular characteristics, the brain tumor microenvironment (TME), and CNS tumor diagnostics. Advances also cover genetic syndromes, medulloblastoma, and the tumor microbiome.

Keywords:
Brain tumorCOVID-19GliomaMedulloblastomaMolecular diagnosticsTumor microenvironment

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Area of Science:

  • Neuro-oncological pathology
  • Neuroscience
  • Clinical Neuro-oncology

Background:

  • 2020 saw significant advancements in understanding brain tumors.
  • Key areas of focus included molecular pathology, tumor immunology, and diagnostics.

Purpose of the Study:

  • To highlight the top 10 discoveries in neuro-oncological pathology from 2020.
  • To provide an overview of significant research in neurosciences and clinical neuro-oncology relevant to neuro-oncological pathology.

Main Methods:

  • Review and selection of 10 key publications from 2020.
  • Categorization of discoveries based on molecular characteristics, tumor microenvironment, diagnostics, and genetic predispositions.

Main Results:

  • New molecular insights into various glioma types (IDH-mutant, pediatric, infant-type, hypermutation).
  • Advances in understanding the brain tumor microenvironment (TME) and its impact on models.
  • Progress in liquid biopsy for central nervous system (CNS) tumors and the role of the microbiome.
  • Identification of new genetic syndromes linked to medulloblastoma.

Conclusions:

  • The year 2020 yielded substantial progress in neuro-oncological pathology.
  • Continued research into molecular and immunological aspects is crucial for advancing brain tumor treatment.
  • Emerging technologies like liquid biopsy and microbiome analysis offer new diagnostic avenues.