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Marilyn Naeem1, Nicholas A Anas2, Andrew R Chadeayne2

  • 1University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02747, USA.

Iucrdata
|June 8, 2023
PubMed
Summary
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The crystal structure of N-methyl-serotonin hydrogen oxalate reveals its solid-state arrangement. Molecules form a 3D network through hydrogen bonds between the protonated serotonin cation and oxalate anion.

Area of Science:

  • Crystallography
  • Structural Chemistry
  • Neuroscience

Background:

  • N-methyl-serotonin is a derivative of the neurotransmitter serotonin.
  • Understanding the solid-state structure of such compounds is crucial for pharmaceutical development and chemical analysis.

Purpose of the Study:

  • To determine and report the precise solid-state structure of N-methyl-serotonin hydrogen oxalate.
  • To elucidate the intermolecular interactions governing the crystal packing.

Main Methods:

  • Single-crystal X-ray diffraction was employed to analyze the compound.
  • The crystal structure was solved and refined to determine atomic positions and bonding.

Main Results:

  • The asymmetric unit contains one singly protonated N-methylserotonin cation and one hydrogen oxalate anion.
Keywords:
crystal structurehydrogen bondingindolestryptamines

Related Experiment Videos

  • The crystal lattice is characterized by a three-dimensional network formed by N-H⋯O and O-H⋯O hydrogen bonds.

    • Conclusions:

    • The study provides a detailed understanding of the hydrogen bonding network in crystalline N-methyl-serotonin hydrogen oxalate.
    • This structural information can inform future research on serotonin derivatives and their solid-state properties.