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ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

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4-Hy-droxy-N,N-diiso-propyl-tryptammonium hydro-fumarate.

Marilyn Naeem1, Andrew R Chadeayne2, James A Golen1

  • 1University of Massachusetts Dartmouth 285 Old Westport Road North Dartmouth MA 02747 USA.

Iucrdata
|July 9, 2025
PubMed
Summary
This summary is machine-generated.

The solid-state structure of a tryptammonium salt was determined. Hydrogen bonds between anions and cations form a complex three-dimensional network in the crystal structure.

Keywords:
crystal structurehydrogen bondingindolestryptamines

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Area of Science:

  • Crystallography
  • Solid-state chemistry
  • Supramolecular chemistry

Background:

  • Understanding the solid-state structure of organic salts is crucial for predicting their physical properties.
  • Tryptammonium derivatives are of interest due to their potential biological and pharmaceutical applications.

Purpose of the Study:

  • To report the crystal structure of a specific tryptammonium hydrofumarate salt.
  • To analyze the intermolecular interactions, particularly hydrogen bonding, within the crystal lattice.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the atomic arrangement.
  • Analysis of hydrogen bonding networks (O-H···O and N-H···O) was performed.

Main Results:

  • The systematic name of the salt is [2-(4-hydroxy-1H-indol-3-yl)ethyl]bis-(propan-2-yl)azanium (2E)-3-carboxy-prop-2-enoate.
  • Hydrofumarate anions form linear chains via O-H···O hydrogen bonds.
  • These chains, along with tryptammonium cations, create a 3D network through O-H···O and N-H···O hydrogen bonds.

Conclusions:

  • The study elucidates the intricate hydrogen bonding network governing the solid-state architecture of this tryptammonium salt.
  • The findings contribute to the understanding of structure-property relationships in organic crystalline materials.