Related Experiment Video
Updated: Jul 26, 2025
12:08
Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
9.3K
Cancer immunity derailed: PGE2 misconducts cDC1s
Matthew Brown1, Michelle A Tran1, Nina Bhardwaj2
1Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Immunity
|June 14, 2023
Summary
Prostaglandin E2 creates dysfunctional type 1 conventional dendritic cells (cDC1s), hindering CD8+ T cell responses crucial for tumor control. This dysfunction promotes cancer progression by impairing immune cell coordination.
Area of Science:
- Immunology
- Cancer Biology
- Cellular Biology
Background:
- Type 1 conventional dendritic cells (cDC1s) are essential for initiating anti-tumor CD8+ T cell immunity.
- Dysfunctional immune responses contribute to tumor progression and immune evasion.
Purpose of the Study:
- To elucidate the mechanism by which prostaglandin E2 (PGE2) impacts cDC1 function in the tumor microenvironment.
- To understand how PGE2-induced cDC1 dysfunction contributes to cancer progression.
Main Methods:
- In vivo and in vitro studies involving mouse models of cancer.
- Analysis of cDC1 phenotype, function, and migratory capacity.
- Assessment of CD8+ T cell expansion and tumor infiltration.
Main Results:
- Prostaglandin E2 (PGE2) was found to induce a dysfunctional state in cDC1s.
- Dysfunctional cDC1s failed to effectively coordinate CD8+ T cell migration and expansion.
- This impaired immune coordination facilitated tumor progression.
Conclusions:
- PGE2-mediated cDC1 dysfunction represents a novel mechanism of immune suppression in cancer.
- Targeting PGE2 signaling or restoring cDC1 function could be a therapeutic strategy for enhancing anti-tumor immunity.
Related Concept Videos
01:27Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
01:30Cancer Vaccines
434
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
434
02:40Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
01:24T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K