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Systemic Diclofenac Sodium Reduces Postoperative rhBMP-2 Induced Neuroinflammation: A Rodent Model Study
Glen Liau Zi Qiang1, Sherry Liu Jiani1, Wing Moon Raymond Lam2
1University Spine Centre, University Orthopaedics, Hand and Reconstructive Microsurgery Cluster, National University Hospital System, Singapore, Singapore.
Spine
|June 16, 2023
Summary
This study shows diclofenac sodium effectively reduces neuroinflammation caused by recombinant human bone morphogenetic protein-2 (rhBMP-2) in rats. This finding may help manage rhBMP-2-induced radiculitis, a complication of spinal fusion surgery.
Area of Science:
- Basic science, animal research study.
Background:
- Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used in lumbar fusion surgery.
- rhBMP-2 can cause complications like postoperative radiculitis.
Purpose of the Study:
- To explore the effectiveness of nonsteroidal anti-inflammatory drugs in reducing rhBMP-2-induced neuroinflammation in rodent models.
Main Methods:
- Eighteen rats underwent surgical intervention with rhBMP-2.
- Rats were randomized into low-dose diclofenac sodium, high-dose diclofenac sodium, or saline groups.
- Neuroinflammation was assessed using thermal withdrawal testing, seroma volume measurement, and histological analysis.
Main Results:
- Diclofenac sodium reduced seroma volume and inflammatory markers.
- High-dose diclofenac sodium showed the lowest macrophage density and minimal demyelination.
- Functional testing revealed significant improvement in the high-dose group, with minimal change in thermal withdrawal latency.
Conclusions:
- Diclofenac sodium is effective in alleviating rhBMP-2-induced neuroinflammation.
- This study presents a viable rodent model for evaluating anti-inflammatory drugs.
- Findings may impact clinical management of rhBMP-2-induced radiculitis.
