Related Experiment Video
Updated: Jul 25, 2025

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
Published on: June 23, 2012
Inferring Recombination Events in SARS-CoV-2 Variants In Silico
Nihal Najeeb1, Aparna B Murukan1, Anagha Renjitha1
1Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Clappana, Kerala, India.
Abstract:
Over the last 34 months, at least 10 severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) distinct variants have evolved. Among these, some were more infectious while others were not. These variants may serve as candidates for identification of the signature sequences linked to infectivity and viral transgressions. Based on our previous hijacking and transgression hypothesis, we aimed to investigate whether SARS-CoV-2 sequences associated with infectivity and trespassing of long noncoding RNAs (lncRNAs) provide a possible recombination mechanism to drive the formation of new variants. This work involved a sequence and structure-based approach to screen SARS-CoV-2 variants in silico, taking into account effects of glycosylation and links to known lncRNAs. Taken together, the findings suggest that transgressions involving lncRNAs may be linked with changes in SARS-CoV-2-host interactions driven by glycosylation events.
More Related Videos
Related Concept Videos
Viral Recombination
Single Nucleotide Polymorphisms-SNPs
Evolutionary Relationships through Genome Comparisons
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Viral Mutations

