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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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The Emerging Roles of Ferroptosis in Neonatal Diseases

Wenqian Chen1, Dali Zheng2, Changyi Yang1

  • 1Department of Neonatology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Journal of Inflammation Research
|July 3, 2023
PubMed

Insights

Ferroptosis, a cell death process, impacts newborns due to unique iron and reactive oxygen species metabolism. Targeting ferroptosis offers new treatment avenues for infant diseases like hypoxic-ischemic encephalopathy.

Area of Science:

  • Cell Biology
  • Neonatal Medicine
  • Pathophysiology

Background:

  • Ferroptosis is a regulated cell death pathway involving lipid peroxidation and iron metabolism.
  • Newborns exhibit unique physiological states, increasing susceptibility to ferroptosis.
  • Ferroptosis is implicated in several neonatal diseases, including HIE, BPD, and NEC.

Purpose of the Study:

  • To review the molecular mechanisms of ferroptosis.
  • To examine iron and reactive oxygen species metabolism in infants.
  • To explore the role of ferroptosis in neonatal disorders and potential therapeutic targets.

Main Methods:

  • Systematic literature review.
  • Analysis of molecular mechanisms of ferroptosis.
  • Synthesis of data on infant metabolism and disease pathology.

Main Results:

  • Ferroptosis is characterized by lipid peroxidation and iron dysregulation.
  • Infant physiology predisposes them to ferroptosis-related damage.
  • Ferroptosis is linked to hypoxic-ischemic encephalopathy, bronchopulmonary dysplasia, and necrotizing enterocolitis.

Conclusions:

  • Ferroptosis plays a significant role in neonatal disease pathogenesis.
  • Understanding ferroptosis mechanisms is crucial for developing novel infant therapies.
  • Targeting ferroptosis presents a promising therapeutic strategy for neonatal conditions.

Keywords:
ferroptosisiron metabolismlipid peroxidationneonatal diseasereactive oxygen species

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