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Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and
Shihong Xu1,2, Yaoyao Liu1,2, Yan Yang1,2
1State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China.
Micromachines
|July 8, 2023
Summary
Neural chip platforms integrate microfluidics and microelectrodes for advanced neuroscience research. These platforms enable in vitro neural network customization, monitoring, and modulation, aiding drug screening and disease diagnosis.
Area of Science:
- Neuroscience
- Bioengineering
- Materials Science
Background:
- The complexity of the brain and ethical constraints of in vivo research necessitate advanced in vitro models.
- Neural chip platforms integrating microfluidic devices and microelectrode arrays offer solutions for studying neural networks.
- These platforms allow customized neuron growth, monitoring, and modulation of neural activity.
Purpose of the Study:
- To review the developmental history of neural chip platforms integrating microfluidic devices and microelectrode arrays.
- To summarize the latest design patterns and fabrication schemes for these platforms.
- To highlight recent progress and applications in brain science and neuroscience.
Main Methods:
- Review of advanced microelectrode array designs and microfluidic device applications.
- Introduction to the fabrication processes of neural chip platforms.
- Analysis of recent advancements in neural chip platform research tools.
Main Results:
- Detailed review of neural chip platforms, covering design, fabrication, and applications.
- Focus on applications in neuropharmacology, neurological diseases, and simplified brain models.
- Identification of key progress in using these platforms as research tools in neuroscience.
Conclusions:
- Neural chip platforms are crucial for overcoming limitations in brain research.
- These platforms provide a versatile tool for drug screening, disease diagnosis, and brain-computer interfaces.
- Future development directions for integrated neural chip platforms are proposed.
