Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2023.2

Area of Science:

• Clinical Practice Guidelines
• Evidence-Based Medicine
• Oncology

Background:

• Rapidly evolving evidence necessitates dynamic clinical practice updates.
• Traditional guidelines may not keep pace with the latest research findings.
• Continuous literature review is crucial for maintaining guideline relevance.

Purpose of the Study:

• To describe the methodology and framework for developing and updating living guidelines.
• To ensure clinical practice reflects the most current scientific evidence.
• To provide a sustainable model for guideline dissemination.

Main Methods:

• Systematic, continuous review of health literature by a standing expert panel.
• Development based on the ASCO Guidelines Methodology Manual.
• Adherence to the ASCO Conflict of Interest Policy for Clinical Practice Guidelines.

Main Results:

• Living guidelines are updated on a regular schedule.
• Updates are published regularly and accessible online.
• The methodology ensures a dynamic and responsive approach to guideline development.

Conclusions:

• Living guidelines offer a robust framework for managing rapidly evolving evidence in medicine.
• This approach supports timely integration of new research into clinical practice.
• Guidelines are intended to supplement, not replace, provider judgment.