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Updated: Jul 23, 2025

Deriving Retinal Pigment Epithelium RPE from Induced Pluripotent Stem iPS Cells by Different Sizes of Embryoid Bodies
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Deriving Retinal Pigment Epithelium RPE from Induced Pluripotent Stem iPS Cells by Different Sizes of Embryoid Bodies

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CD68: Potential Contributor to Inflammation and RPE Cell Dystrophy

Mayur Choudhary1, Goldis Malek2,3

  • 1Department of Ophthalmology, Albert Eye Research Institute, Duke University School of Medicine, Durham, NC, USA.

Advances in Experimental Medicine and Biology
|July 13, 2023
PubMed

Insights

CD68, a marker for macrophages, may play a role in regulating retinal health and inflammation in age-related macular degeneration (AMD). Further research is needed to clarify its function in AMD pathogenesis.

Area of Science:

  • Ophthalmology
  • Immunology
  • Cell Biology

Background:

  • Age-related macular degeneration (AMD) is a primary cause of vision loss in older adults, driven by complex inflammatory processes.
  • CD68 is a myeloid marker found on macrophages, crucial immune cells involved in inflammation.
  • Previous studies on CD68 in AMD tissues have yielded conflicting results regarding its presence and role.

Approach:

  • This review synthesizes current knowledge on CD68's function in retinal health and inflammation.
  • It examines observations of CD68 localization in a mouse model exhibiting AMD-like characteristics.
  • The review discusses the potential involvement of CD68 in regulating retinal pigment epithelium (RPE) health.

Key Points:

  • CD68 is highly expressed in macrophages, key players in inflammatory responses.
  • Conflicting data exists on CD68 expression in human AMD tissues.
  • Animal models suggest CD68 upregulation in protective retinal microglia.

Conclusions:

  • CD68's precise role in AMD pathogenesis requires further investigation.
  • Understanding CD68's function could offer new therapeutic targets for AMD.
  • This review highlights the need for continued research into immune cell involvement in AMD.
Keywords:
Age-related macular degenerationCD68InflammationRetinal pigment epithelial cellsSub-retinal immune cells

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