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Inducing Neural Regeneration from Glia Using Proneural bHLH Transcription Factors

Levi Todd1

  • 1Department of Biological Structure, University of Washington, Seattle, WA, USA. ljtodd@uw.edu.

Advances in Experimental Medicine and Biology
|July 13, 2023
PubMed

Keywords:
AstrocyteGliaMüller gliaNG2NeurodegenerationRegenerationReprogrammingRetinabHLH Transcription factor

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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