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Asthma as a Systemic Disease: Cardiovascular Effects Associated with Asthma
1University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. tattersall@wisc.edu.
Advances in Experimental Medicine and Biology
|July 18, 2023
Summary
Asthma patients face higher cardiovascular disease (CVD) risks due to systemic inflammation. Identifying high-risk individuals with asthma is crucial for targeted prevention and treatment of CVD.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Public Health
Background:
- Asthma and cardiovascular disease (CVD) are major public health concerns.
- Systemic inflammation in asthma contributes to CVD pathophysiology.
- Epidemiological studies link asthma to adverse cardiovascular outcomes like arterial injury, atherosclerotic events, atrial fibrillation, and hypertension.
Purpose of the Study:
- To explore the complex relationship between asthma and CVD risk.
- To address the heterogeneity of CVD risk across asthma phenotypes and endotypes.
- To emphasize the need for a precision medicine approach in managing CVD risk in asthma patients.
Main Methods:
- Review of epidemiological studies and pathophysiological mechanisms.
- Analysis of cardiovascular effects associated with asthma.
- Examination of clinical phenotypes and molecular endotypes of asthma.
Main Results:
- Asthma is associated with increased risk of various cardiovascular diseases.
- CVD risk is not uniform across all asthma subtypes.
- Mechanisms linking asthma and CVD are multifactorial and not fully understood.
Conclusions:
- A precise approach is needed to identify asthma patients at high risk for CVD.
- Targeted diagnostic and preventive strategies are essential to reduce CVD burden in asthma.
- Further research is required to elucidate the multifactorial mechanisms underlying CVD risk in asthma.
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