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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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Perforating Gout: Expanding the Differential for Transepidermal Elimination.
Michal Bohdanowicz1, Scott H Bradshaw1
1Department of Medicine, Sunnybrook Campus, University of Toronto, 2075 Bayview Ave., Toronto, ON M4N 3N5, Canada.
Dermatopathology (Basel, Switzerland)
|July 25, 2023
Summary
Perforating dermatoses involve transepidermal elimination of dermal substances. This case highlights perforating tophaceous gout, emphasizing a broad differential for these skin conditions.
Area of Science:
- Dermatology
- Pathology
Background:
- Perforating dermatoses are characterized by transepidermal elimination (TE) of dermal substances.
- While typically involving collagen and elastin, TE can be secondary to other processes.
Observation:
- A case of perforating tophaceous gout was identified.
- This presentation required a broad differential diagnosis for perforating disorders.
Findings:
- Perforating tophaceous gout is a rare manifestation of skin disease.
- The case underscores the importance of considering diverse etiologies in TE.
Implications:
- Clinicians should maintain a broad differential for patients presenting with perforating dermatoses.
- Recognizing secondary TE is crucial for accurate diagnosis and management of skin conditions.
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