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Autism Spectrum Disorder in Children With Perinatal Ischemic Stroke Varies by Stroke Type
Clara M Wu1, Bo Zhang1,2, Cameron C Trenor2,3,4
1Neurology Department, Boston Children's Hospital, Boston, MA, USA.
Journal of Child Neurology
|July 27, 2023
Summary
Children with perinatal venous stroke show a higher likelihood of developing autism spectrum disorder (ASD) compared to those with arterial stroke. This finding highlights the importance of considering stroke type in neurodevelopmental assessments.
Area of Science:
- Neurology
- Pediatrics
- Developmental Neuroscience
Background:
- Perinatal stroke is a significant cause of lifelong neurodevelopmental disorders in children.
- Limited research exists on the prevalence of autism spectrum disorder (ASD) following perinatal stroke.
- Clinical observations prompted an investigation into ASD rates in pediatric stroke patients.
Purpose of the Study:
- To determine the rate of autism spectrum disorder (ASD) diagnosis in children with perinatal ischemic stroke.
- To analyze the association between different perinatal ischemic stroke subtypes and ASD diagnosis.
Main Methods:
- Retrospective analysis of children diagnosed with perinatal ischemic stroke (≥18 months at last follow-up, 2008-2021).
- ASD diagnosis confirmed by neurologists, neuropsychologists, psychologists, or developmental pediatricians.
- Multivariable logistic regression used to assess stroke subtype and ASD association.
Main Results:
- Out of 260 children with perinatal stroke, 19 (7.3%) were diagnosed with ASD.
- Children with perinatal venous stroke had triple the odds of ASD compared to those with perinatal arterial ischemic stroke (aOR: 3.01, 95% CI: 1.07-8.47).
Conclusions:
- Perinatal venous stroke is associated with increased odds of autism spectrum disorder compared to perinatal arterial ischemic stroke.
- Further prospective research is necessary to elucidate the role of perinatal stroke in ASD development.
