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Automated Laser-Fiber Coupling Module for Optical-Resolution Photoacoustic Microscopy.

Seongyi Han1, Hyunjun Kye1, Chang-Seok Kim1

  • 1Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea.

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|July 29, 2023
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Summary
This summary is machine-generated.

This study introduces an automated module for laser-fiber coupling in photoacoustic microscopy. It enhances image quality and efficiency by optimizing laser delivery, reducing manual adjustments for biomedical imaging.

Keywords:
laser deliverylaser-fiber couplingoptical fiberphotoacoustic microscopy

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Area of Science:

  • Biomedical Imaging
  • Optical Physics
  • Engineering

Background:

  • Photoacoustic imaging visualizes optical absorption in tissues.
  • Optical-resolution photoacoustic microscopy offers high spatial resolution.
  • Efficient laser delivery is crucial for high-quality photoacoustic images.

Purpose of the Study:

  • To develop an automated laser-fiber coupling module for optical-resolution photoacoustic microscopy.
  • To optimize laser delivery and minimize manual intervention.
  • To improve the efficiency and robustness of photoacoustic imaging systems.

Main Methods:

  • Incorporation of a motor-mounted mirror holder for automated alignment.
  • Implementation of proportional-derivative (PD) control for precise laser delivery.
  • Evaluation using a leaf-skeleton phantom (in vitro) and a human finger (in vivo).

Main Results:

  • Successful achievement of efficient and robust laser delivery.
  • Demonstration of high-quality photoacoustic images from both phantom and in vivo samples.
  • Significant reduction in the need for manual adjustments in the coupling process.

Conclusions:

  • The automated laser-fiber coupling module enhances the quality and efficiency of optical-resolution photoacoustic microscopy.
  • This innovation streamlines the setup process, making photoacoustic imaging more accessible.
  • The system shows potential for broader applications in biomedical research and clinical diagnostics.