[Rhabdomyosarcoma of the prostate]

Area of Science:

• Urology
• Oncology
• Pathology

Background:

• Rhabdomyosarcoma is a rare malignancy, particularly in adults, and its occurrence in the prostate is exceptionally uncommon.
• Prostate rhabdomyosarcoma can present with non-specific symptoms, potentially delaying diagnosis.

Observation:

• A 56-year-old male presented with anal pain and dysuria, raising suspicion for a prostate tumor.
• Rectal examination suggested a prostate mass, and imaging revealed widespread metastatic lesions in the lungs and liver.
• Needle biopsy confirmed the diagnosis of rhabdomyosarcoma of the prostate.

Findings:

• The patient received Etoposide chemotherapy with minimal response.
• Subsequent VAC (Vincristine, Dactinomycin, Cyclophosphamide) therapy resulted in temporary improvement.
• The patient's condition deteriorated, and he died 4 months after initial admission due to the aggressive nature of the disease.

Implications:

• This case highlights the challenges in diagnosing and treating rare adult prostate malignancies.
• Prostate rhabdomyosarcoma, though infrequent, should be considered in the differential diagnosis of prostate tumors with rapid progression and metastasis.
• Further research into effective therapeutic strategies for this rare cancer is warranted.