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Health state utilities associated with hyperphagia: Data for use in cost-utility models.
Timothy A Howell1, Louis S Matza1, Usha G Mallya2
1Patient-Centered Research Evidera Bethesda Maryland USA.
Obesity Science & Practice
|August 7, 2023
Summary
This study quantifies health state utilities for hyperphagia, a symptom of rare genetic obesity. Decreasing utilities correlate with increasing hyperphagia severity, impacting quality of life.
Area of Science:
- Health Economics
- Genetics
- Quality of Life Research
Background:
- Rare genetic diseases of obesity often involve hyperphagia, a pathological urge to eat.
- Cost-utility models require health state utilities to assess treatment value for these conditions.
- Quantifying the impact of hyperphagia severity on quality of life is crucial for economic evaluations.
Purpose of the Study:
- To estimate health state utilities associated with varying levels of hyperphagia severity.
- To provide data for cost-utility analyses of treatments for rare genetic obesity.
Main Methods:
- Developed four health state vignettes representing different hyperphagia severities.
- Conducted a time trade-off elicitation study with 215 UK general population participants.
- Collected demographic data including age and gender.
Main Results:
- Mean utilities decreased with increasing hyperphagia severity: no hyperphagia (0.98), mild (0.91), moderate (0.70), and severe (0.22).
- Disutilities were -0.08 (mild), -0.28 (moderate), and -0.77 (severe).
- Severe hyperphagia utilities were comparable to other conditions with significant quality of life impacts.
Conclusions:
- Increasing hyperphagia severity is linked to reduced health state utility.
- Severe hyperphagia substantially diminishes quality of life, necessitating targeted treatments.
- Estimated utilities can inform cost-utility models for rare genetic obesity treatments.
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