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Updated: Jul 19, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Mammary carcinoma: toward a realistic mouse model of incurable cancers
Maria Pérez-Lanzón1,2, Maria Chiara Maiuri1,2,3, Carlos Lopez-Otin4
1Centre de Recherche des Cordeliers, Équipe Labellisée Par la Ligue Contre le Cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France.
Abstract:
As long as breast cancer (BC) stays under immunosurveillance, it can be controlled by treatments eliciting anticancer immune responses. However, once BC escapes immunosurveillance, it becomes therapeutically uncontrollable. A paper in the Journal for ImmunoTherapy of Cancer describes a new hormone receptor-positive BC cell line generating incurable tumors in C57BL/6 mice.
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