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Updated: Jul 19, 2025
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Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
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Off-target pharmacological activity at various kinases: Potential functional and pathological side effects
Jonathon R Green1, Prathap Kumar S Mahalingaiah1, Sujatha M Gopalakrishnan2
1Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Journal of Pharmacological and Toxicological Methods
|August 8, 2023
Summary
This study summarizes potential functional and pathological outcomes from interacting with 95 kinases. It serves as a guide for drug discovery scientists to predict adverse effects from small molecule kinase interactions.
Area of Science:
- Pharmacology
- Drug Discovery
- Biochemistry
Background:
- Small molecules are screened for off-target interactions during drug discovery.
- Kinase interactions can cause unintended safety findings in later development stages.
Purpose of the Study:
- To create a compendium of functional and pathological outcomes associated with kinase interactions.
- To guide scientists in predicting and interpreting adverse effects from small molecule kinase interactions.
Main Methods:
- Extensive curation of scientific literature.
- Review of online databases for kinase-related functional and pathological effects.
- Summarization of the most frequently reported effects for 95 kinases.
Main Results:
- A comprehensive guide detailing likely outcomes of kinase interactions.
- Data based on safety information and institutional knowledge.
- Focus on 95 kinases identified by AbbVie.
Conclusions:
- The compendium aids drug discovery scientists and clinical investigators.
- Facilitates prediction and interpretation of adverse effects.
- Enhances understanding of kinase-targeted drug safety profiles.
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