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Related Concept Videos

Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

244
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
244
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

223
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
223

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Related Experiment Video

Updated: Jul 18, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

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Neonatal serious illness: operational definition.

Katherine Guttmann1, Rachel Silverman2, Andrea S Weintraub2

  • 1Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA katherine.guttmann@mssm.edu.

BMJ Supportive & Palliative Care
|August 24, 2023
PubMed
Summary
This summary is machine-generated.

Neonatal serious illness criteria were met early in life for all infants studied. This definition may help identify neonates needing support, though further research is needed.

Keywords:
End of life careHospital carePaediatricsPrognosis

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Area of Science:

  • Neonatal Medicine
  • Palliative Care
  • Serious Illness Definitions

Background:

  • Defining serious illness in neonates is crucial for timely intervention.
  • Previous work established a definition for neonatal serious illness.
  • Operationalizing this definition in a patient cohort is necessary.

Purpose of the Study:

  • To apply a previously published definition of neonatal serious illness to a patient cohort.
  • To evaluate the timing of palliative care consultations and goals of care discussions.
  • To assess the timeliness of meeting serious illness criteria in neonates.

Main Methods:

  • Retrospective chart review of inborn neonates who died before NICU discharge (2006-2020).
  • Used statistical tests (Kruskal-Wallis, Mann-Whitney-U, χ²) to compare time intervals and frequencies.
  • Identified patients meeting serious illness criteria via EPIC query.

Main Results:

  • 88% of neonates met serious illness criteria within 48 hours of life.
  • No significant difference in transition to serious illness between preterm and term infants.
  • Palliative care was consulted in only 5.7% of cases.

Conclusions:

  • The established definition identified all patients as having serious illness early in life.
  • The definition shows potential for identifying neonates needing support.
  • Prospective application is recommended to explore clinical and research utility.