Dermatomyositis with intrahepatic cholangiocarcinoma: a case report and data mining based on machine learning

Area of Science:

• Oncology
• Rheumatology
• Genomics

Background:

• Paraneoplastic dermatomyositis (DM) links autoimmune disease with cancer.
• Intrahepatic cholangiocarcinoma (ICC) is rarely reported in association with DM.

Observation:

• A case of a middle-aged female patient with a 7-year history of DM who subsequently developed ICC is presented.
• Gene Expression Omnibus (GEO) database analysis explored the molecular mechanisms linking DM and ICC.

Findings:

• Machine learning identified poly(ADP-ribose) polymerase family member 12 (PARP12) and metallothionein 1M (MT1M) as significantly associated with DM-secondary ICC.
• PARP12 and MT1M show potential as predictive biomarkers for ICC in DM patients.

Implications:

• These findings may improve early detection of ICC in DM patients.
• Understanding the molecular link between DM and ICC could lead to targeted therapies.