Autoantibodies in psoriatic disease

Area of Science:

• Immunology
• Dermatology
• Rheumatology

Background:

• Psoriasis affects millions, with psoriatic arthritis (PsA) in about 25% of cases.
• Psoriatic disease is immune-mediated, showing both autoimmune and autoinflammatory traits.
• Historically, psoriatic disease is considered rheumatoid factor-negative.

Approach:

• This review examines current literature on autoantibodies in psoriatic disease.
• It analyzes the frequency and clinical significance of autoantibodies in psoriasis and PsA.
• The review also covers antibody assay principles and study methodologies.

Key Points:

• An array of autoantibodies has been identified in psoriatic disease patients.
• These autoantibodies may indicate an autoimmune component in the disease.
• Their clinical significance for diagnosis, activity, and treatment response is explored.

Conclusions:

• While autoantibodies are present in psoriatic disease, their clinical utility requires further investigation.
• The findings suggest a potential autoimmune contribution to psoriatic disease pathogenesis.
• More research is needed to establish the definitive role and application of these autoantibodies.