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Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
Forough Saki1, Mesbah Shams1, Sanaz Dastghaib1
1Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Biomed Research International
|September 15, 2023
Summary
Pantoprazole causes bone loss by increasing gastrin secretion, a condition that can be prevented by octreotide. This study investigated the link between pantoprazole, gastrin, and bone density in rats.
Area of Science:
- Endocrinology
- Bone Biology
- Pharmacology
Background:
- Proton pump inhibitors (PPIs) are linked to bone loss, but the mechanism remains unclear.
- Pantoprazole's effect on gastrin secretion suggests a potential pathway for bone loss.
Purpose of the Study:
- To investigate if pantoprazole induces bone loss via gastrin secretion.
- To determine the efficacy of octreotide in preventing pantoprazole-induced bone loss.
Main Methods:
- Forty male rats were divided into four groups: control, octreotide, pantoprazole, and pantoprazole plus octreotide.
- Biochemical markers (calcium, phosphorous, alkaline phosphatase, PTH, gastrin) and bone densitometry were measured.
- Femoral bone structure was stereologically analyzed.
Main Results:
- Pantoprazole significantly increased alkaline phosphatase, PTH, and gastrin levels, which octreotide counteracted.
- Bone densitometry revealed significant bone loss in the pantoprazole group, mitigated by octreotide.
- Pantoprazole reduced trabecular bone volume and femur bone weight, increased osteoclast count, and decreased osteocyte number.
Conclusions:
- Pantoprazole induces bone loss, likely mediated by hypergastrinemia.
- Octreotide effectively prevents pantoprazole-induced bone loss, supporting the role of gastrin.
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