Related Experiment Video
Updated: Jul 15, 2025

Intraductal Delivery to the Rabbit Mammary Gland
Published on: March 9, 2017
Malignus emlőtumor? Gyulladásos emlőelváltozás? Ritka benignus kórkép?
Edina Zita Kiss1, Ákos Botos1, Zoltán Szöllősi2
11Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház, Sebészeti Osztály, Miskolc, Magyarország.
Case-Report:
Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy is a rare, benign non-Langerhans cell histiocytosis, that typically involves the lymph nodes, but may also involve extranodal sites. We present a 58- years- old female patient who complained of a palpable mass in her left breast surrounded by 15-20 livid cutaneous lesions, resembling malignant breast cancer with cutaneous metastasis. Despite of core biopsy of the tumor and excisional biopsy one of the lesions, correct diagnosis of RDD was achieved only by complete pathological examination of the whole lesion after surgical excision.
Conclusion:
Rosai-Dorfman disease confined to the breast is extremely rare, that clinically may mimic breast cancer.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Disorders of the Female Reproductive System
The Mammary Glands
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

