Recent Advances in Bioelectronics for Localized Drug Delivery

Area of Science:

• Bioelectronics
• Biomedical Engineering
• Materials Science

Background:

• Bioelectronics has seen significant progress in wearable and implantable devices for drug delivery.
• Miniaturized and flexible bioelectronic systems enable ideal integration with organs and tissues for localized administration.
• Electrically assisted drug delivery enhances efficiency and safety, particularly for macromolecules facing biological barriers.

Purpose of the Study:

• To provide a concise overview of recent advancements in bioelectronic devices for in vivo localized drug delivery.
• To highlight the latest trends in device design, working principles, and functionalities.
• To categorize systems based on targeted delivery locations: wearable, ingestible, and implantable.

Main Methods:

• Review of recent literature on bioelectronic devices for localized drug delivery.
• Categorization of systems by targeted delivery location (wearable, ingestible, implantable).
• Detailed discussion of device requirements and solutions for each category.

Main Results:

• Bioelectronic devices are increasingly integrated with biological systems for targeted drug delivery.
• Electrically assisted drug delivery shows promise for overcoming challenges with macromolecule penetration.
• Systems are categorized into wearable, ingestible, and implantable types, each with specific design considerations.

Conclusions:

• Bioelectronics represents a new era for localized drug delivery, enhancing therapeutic administration.
• Continued innovation in device design and electrical assistance is crucial for overcoming biological barriers.
• Addressing remaining challenges and exploring future directions will further advance the field of bioelectronic drug delivery.