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Chronic Wound Management: From Gauze to Homologous Cellular Matrix
Valentin Popescu1,2, Victor Cauni3, Marius Septimiu Petrutescu1
1General Surgery Clinic, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Biomedicines
|September 28, 2023
Summary
Chronic wound management is advancing with regenerative medicine, stem cell therapies, and AI. Combining these modern approaches with systemic support accelerates healing and improves patient outcomes.
Area of Science:
- Wound Healing and Regenerative Medicine
- Biotechnology and Medical Devices
- Health Services Research
Background:
- Chronic wounds pose significant health challenges, leading to increased healthcare costs, reduced quality of life, and impaired patient mobility.
- Prolonged healing times, infection risks, and functional deficits associated with chronic wounds are major concerns for healthcare providers.
- The economic and personal burden of chronic wounds necessitates innovative and effective management strategies.
Purpose of the Study:
- To conduct a multi-perspective analysis of existing medical literature on chronic wound management.
- To evaluate the efficacy of a wide range of wound care therapies, from traditional methods to cutting-edge regenerative approaches.
- To synthesize current knowledge on advanced wound healing technologies and their potential impact.
Main Methods:
- A systematic review of 48 articles published within the last 21 years from MEDLINE and Global Health databases.
- Inclusion criteria focused on studies with a minimum of 20 citations, adult patients (>18 years), and chronic, complex, hard-to-heal wounds.
- Data were extracted and summarized using a narrative synthesis approach, incorporating health-related quality of life measures.
Main Results:
- Evaluated therapies range from classical methods to regenerative medicine utilizing stem cells and growth factors.
- Modern wound healing arsenal includes regenerative medicine, stem cell therapies, biologic dressings, negative pressure wound therapy (NPWT), electrical stimulation, topical growth factors, hyperbaric oxygen therapy (HBOT), advanced dressings, artificial intelligence (AI), and digital wound management.
- Significant advancements in wound care products and technologies are available for managing complex wounds.
Conclusions:
- Periodic medical evaluation and the judicious use of modern therapies are crucial for faster wound healing.
- Plasma-derived products like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), combined with adequate systemic support (nutrition, glycemic control, vitamins), enhance healing.
- Integration of AI in wound management holds the potential to achieve the fastest possible healing rates.
