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Updated: Jul 15, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease
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Next Generation Development of Hybrid Continuous Flow Pediatric Total Artificial Heart Technology: Design-Build-Test.

Matthew D Hirschhorn1, Jonathan E M Lawley2, Andrew J Roof2

  • 1From the BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 29, 2023
PubMed
Summary

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This summary is machine-generated.

Researchers developed the "Dragon Heart," a hybrid artificial heart for pediatric circulatory support. This novel device integrates axial and centrifugal pumps, demonstrating effective tandem operation without performance compromise.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Pediatric Cardiology

Background:

  • Pediatric circulatory support faces unmet clinical needs.
  • Existing devices may not meet all requirements for pediatric patients.
  • Development of novel artificial heart technologies is crucial.

Purpose of the Study:

  • To develop and test a hybrid, continuous-flow, total artificial heart for pediatric use.
  • To integrate and optimize a magnetically levitated centrifugal pump with an existing axial flow pump.
  • To validate the performance of the combined system for pediatric circulatory support.

Main Methods:

  • Utilized computational fluid dynamics and finite element analysis for pump design optimization.
  • Constructed a prototype centrifugal pump using 3D printed biocompatible materials and machined metal components.

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Last Updated: Jul 15, 2025

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  • Performed hydraulic testing with water and bovine blood, evaluating tandem operation of axial and centrifugal pumps.

    • Main Results:

    • Achieved a 50% size reduction in the centrifugal pump through motor integration.
    • Demonstrated successful hydraulic performance of the integrated axial and centrifugal pumps operating in tandem.
    • Confirmed that centrifugal pump performance was not negatively affected by simultaneous axial pump operation.

    Conclusions:

    • The developed centrifugal pump shows promising performance for integration into a hybrid total artificial heart.
    • The prototype "Dragon Heart" demonstrates feasibility for pediatric circulatory support.
    • Future iterations aim for further size reduction and enhanced magnetic levitation capabilities.