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Recent Advances in Photothermal Therapy at Near-Infrared-II Based on 2D MXenes
Nan Li1, Yisen Wang1, Yang Li2
1GBA Branch of Aerospace Information Research Institute, Chinese Academy of Sciences, and Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou, Guangdong, 510700, China.
Small (Weinheim an Der Bergstrasse, Germany)
|September 30, 2023
Summary
Near-infrared II photothermal therapy (PTT) using MXene nanomaterials offers a powerful, noninvasive cancer treatment. This review explores MXene synthesis, PTT mechanisms, and their promising biomedical applications in the NIR-II region.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Photothermal therapy (PTT) is a promising cancer treatment strategy.
- The near-infrared II (NIR-II) region (1000-1700 nm) offers enhanced tissue penetration and reduced background noise for PTT.
- MXenes are emerging 2D inorganic nanomaterials with excellent photothermal conversion efficiency and biocompatibility.
Purpose of the Study:
- To review the synthesis methods of 2D MXenes.
- To introduce the laser light source, photothermal conversion mechanism, and performance evaluation criteria for PTT.
- To summarize the latest progress in NIR-II PTT using 2D MXenes.
Main Methods:
- Summarized synthesis routes for 2D MXenes.
- Detailed laser light sources and photothermal conversion mechanisms.
- Reviewed evaluation criteria for photothermal performance.
Main Results:
- Highlighted the advantages of NIR-II PTT, including deeper tissue penetration and improved safety.
- Showcased PTT applications of specific MXenes like Ti3C2, Nb2C, and Mo2C in the NIR-II region.
- Identified key challenges and future research directions for MXene-based NIR-II PTT.
Conclusions:
- 2D MXenes are highly effective photothermal agents for NIR-II PTT.
- MXene-based NIR-II PTT presents a promising biomedical therapy with significant advantages over traditional PTT.
- Further research is needed to overcome current limitations and optimize MXene applications in this field.
