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Relation between Acute Ischemic Stroke and Left Ventricular Systolic Dysfunction.

M Saiduzzaman1, S Dey, M Bhattacharjee

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Summary
This summary is machine-generated.

Mild to moderate Left Ventricular Systolic Dysfunction (LVSD) increases the risk of acute ischemic stroke. Lower LVEF in stroke patients correlates with more severe neurological deficits, highlighting LVSD as a key factor in stroke development and severity.

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Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Stroke is a leading cause of death and disability globally, with ischemic stroke accounting for 80-85% of cases.
  • While overt heart failure predicts poor outcomes, the link between mild-to-moderate Left Ventricular Systolic Dysfunction (LVSD) and acute ischemic stroke (AIS) risk remains under-researched.
  • Understanding the association between LVSD and AIS is crucial for improving stroke prevention and management strategies.

Purpose of the Study:

  • To investigate the relationship between LVSD and the occurrence of AIS.
  • To evaluate the association between LVSD and the severity of neurological deficits in AIS patients.
  • To determine if mild-to-moderate LVSD is an independent risk factor for AIS.

Main Methods:

  • A case-control study involving 120 first-ever AIS patients and 120 age/sex-matched healthy controls.
  • Assessment of Left Ventricular (LV) systolic function using transthoracic 2-dimensional echocardiography to determine Left Ventricular Ejection Fraction (LVEF).
  • Measurement of stroke severity using the National Institute of Health Stroke Scale (NIHSS).

Main Results:

  • LVSD was significantly more prevalent in AIS patients (23.3%) compared to controls (5.8%, p<0.001).
  • Mild and moderate LVSD were associated with significantly higher odds of AIS (OR 3.48 and 9.74, respectively).
  • LVSD remained an independent risk factor for AIS after adjusting for other risk factors (OR 2.7462, p=0.0435).
  • NIHSS scores showed a significant negative correlation with LVEF (r=-0.443, p<0.001), indicating greater neurological deficit with lower LVEF.

Conclusions:

  • Mild to moderate LVSD is significantly associated with an increased risk of acute ischemic stroke.
  • LVSD is an independent risk factor for AIS, even when other common risk factors are considered.
  • Lower LVEF in AIS patients correlates with more severe neurological deficits, underscoring the impact of cardiac dysfunction on stroke outcomes.