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Total Synthesis of (-)-Enigmazole B

Yoshihiro Goda1, Haruhiko Fuwa1

  • 1Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.

Organic Letters
|October 5, 2023
PubMed
Summary

This study reports the first-ever total synthesis of (-)-enigmazole B, a complex natural product. Key synthetic steps include cross-metathesis, Sonogashira coupling, and gold-catalyzed reactions for constructing the molecule.

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