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Updated: Jul 14, 2025
A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
Published on: July 3, 2016
[Application of deep mutational scanning technology in protein research]
Yifan Li1, Yi Wang1, Kaili Zhang1
1Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
Deep mutational scanning (DMS) analyzes protein sequence variation
Area of Science:
- Molecular Biology
- Biochemistry
- Genetics
Background:
- Proteins are essential for cellular structure and function.
- Understanding how protein sequence variations affect structure and function is crucial.
- Deep mutational scanning (DMS) has emerged as a powerful tool in protein research.
Conclusions:
- Deep mutational scanning (DMS) is a vital method for protein function research and engineering.
- Addressing current technical bottlenecks will further advance DMS utility.
- This review aims to facilitate ongoing research in the field.
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