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Multifunctional Nanoclay-Based Hemostatic Materials for Wound Healing: A Review
Ya Tan1, Qian Yang2, Meng Zheng3,4
1Hunan Key Laboratory of Mineral Materials and Application, School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China.
Advanced Healthcare Materials
|October 10, 2023
Summary
Nanoclay accelerates hemostasis and promotes wound healing by offering antibacterial and anti-inflammatory properties. These multifunctional nanoclay materials are crucial for advanced wound hemostatic dressing design.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Hemorrhage is a leading cause of trauma mortality, with current hemostatic agents often being monofunctional or inadequate.
- Nanoclay presents unique properties for developing multifunctional hemostatic materials.
Purpose of the Study:
- To discuss the chemical design and mechanisms of nanoclay-based materials for hemostasis, antibacterial action, and wound healing.
- To outline physiological processes of hemostasis and wound healing relevant to nanoclay dressing design.
Main Methods:
- Review of nanoclay properties, including morphology, surface charge, and ion release.
- Analysis of nanoclay's role in coagulation, protein/cell interaction, and drug delivery.
- Summary of various nanoclay types and products for wound hemostatic dressings.
Main Results:
- Nanoclay accelerates hemostasis and possesses antibacterial properties via metal ion release.
- Its surface charge facilitates protein/cell interactions, aiding coagulation and tissue repair.
- Microporous nanoclay acts as a drug carrier for inhibiting bacterial growth and promoting tissue regeneration.
Conclusions:
- Nanoclay-based materials offer multifunctional benefits for hemostasis and wound healing.
- Further research into nanoclay composites can advance hemostatic dressings and tissue regeneration therapies.
