Probiotic Improves Skin Oxidation, Elasticity, and Structural Properties in Aging Rats.

Area of Science:

• Biogerontology
• Microbiology
• Dermatology

Background:

• Skin aging is a natural process linked to oxidative stress.
• Probiotics possess antioxidant capabilities through reactive metabolite production.
• Limosilactobacillus fermentum USM 4189 (LF 4189) is investigated for its anti-aging potential.

Purpose of the Study:

• To evaluate the antioxidative effects of LF 4189 in a D-galactose induced senescence rat model.
• To determine if LF 4189 can prevent or mitigate skin aging markers.
• To assess the impact of LF 4189 on oxidative stress and cellular senescence.

Main Methods:

• Utilized a D-galactose senescence-induced rat model.
• Administered Limosilactobacillus fermentum USM 4189 (LF 4189) to aged rats.
• Measured plasma antioxidative activity, lipid peroxidation, skin elasticity, telomere length, apoptosis, and antioxidative enzyme gene expression.

Main Results:

• LF 4189 administration increased plasma antioxidative activity and skin elasticity (P<0.05).
• LF 4189 prevented telomere shortening and reduced apoptotic activity in aged rats.
• LF 4189 decreased the expression of key antioxidative enzyme genes, indicating reduced free radical scavenging needs.

Conclusions:

• Limosilactobacillus fermentum USM 4189 (LF 4189) exhibits significant antioxidative properties.
• LF 4189 demonstrates potential as an anti-aging intervention for improving skin health.
• Probiotics like LF 4189 may offer a dietary approach to combat skin aging and oxidative stress.