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Related Experiment Video

Updated: Jul 12, 2025

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

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An optical nanofibre-enabled on-chip single-nanoparticle sensor.

Ning Liu1, Ni Yao2, Shipeng Wang2

  • 1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhang_lei@zju.edu.cn.

Lab on a Chip
|October 24, 2023
PubMed
Summary

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This summary is machine-generated.

This study presents an optical nanofiber microfluidic sensor for detecting and sizing nanoparticles. The sensor achieves single nanoparticle detection and size analysis, showing potential for virus sensing applications.

Area of Science:

  • Optics and Photonics
  • Nanotechnology
  • Microfluidics

Background:

  • Single-nanoparticle detection is crucial for fundamental physics and biological applications.
  • Existing methods often face limitations in sensitivity and throughput.
  • Microfluidic devices offer precise control over sample handling at the microscale.

Purpose of the Study:

  • To develop and demonstrate an optical nanofiber-enabled microfluidic sensor for nanoparticle detection and sizing.
  • To achieve label-free, high-throughput analysis of nanoparticles in solution.
  • To explore the sensor's potential for biological applications, including virus detection.

Main Methods:

  • Utilizing the evanescent field of an optical nanofiber for nanoparticle scattering detection.

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Related Experiment Videos

Last Updated: Jul 12, 2025

Optical Trapping of Nanoparticles
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  • Employing a microfluidic channel to confine nanoparticles to a femtoliter detection volume.
  • Real-time monitoring of transmitted light intensity changes caused by nanoparticle interaction.
  • Statistical analysis of scattering signals for nanoparticle size determination.

    • Main Results:

    • Successful detection and sizing of individual polystyrene nanoparticles down to 100 nm.
    • Distinguishing between mixtures of nanoparticles with different sizes (200, 500, 1000 nm).
    • Demonstrated high-throughput counting of yeast cells and dual-wavelength detection of fluorescent nanoparticles.
    • Exosomes in solution were successfully detected.

    Conclusions:

    • The optical nanofiber microfluidic sensor enables sensitive, label-free detection and sizing of nanoparticles.
    • The system demonstrates high throughput and potential for multiplexed sensing.
    • This technology holds promise for rapid detection of diverse viruses and other biological analytes.