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Injective Programmable Proanthocyanidin-Coordinated Zinc-Based Composite Hydrogel for Infected Bone Repair.

Yue Wang1,2, Yitao Zhao1,2, Shiyuan Ma1,2

  • 1Department of Histology and Embryology, NMPA Key Laboratory for Safety Evaluation of Cosmetics, School of Basic Medical Sciences, Guangzhou, 510515, P. R. China.

Advanced Healthcare Materials
|October 27, 2023
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Summary
This summary is machine-generated.

New injectable hydrogels combine infection control and bone healing. These proanthocyanidin (PC)-coordinated zinc-based composite hydrogels (ipPZCHs) release antimicrobial ions and promote osteogenesis in infected bone defects.

Keywords:
ROS-responsivenessinfected bone defectsproanthocyanidinsilverzinc oxide

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Infectious Disease Research

Background:

  • Treating infected bone defects requires simultaneous infection control and bone regeneration.
  • Existing methods face challenges in integrating these dual functions effectively.
  • Developing advanced biomaterials is crucial for overcoming these limitations.

Purpose of the Study:

  • To develop injectable, programmable composite hydrogels for infected bone repair.
  • To create a system that integrates antimicrobial properties with osteogenesis promotion.
  • To investigate the reactive oxygen species (ROS)-responsive behavior of the hydrogel system.

Main Methods:

  • Synthesized proanthocyanidin (PC)-coordinated zinc oxide (ZnO) microspheres.
  • Composited PC-coordinated ZnO with thioether-grafted sodium alginate (TSA) to form injectable hydrogels (ipPZCHs).
  • Utilized calcium chloride (CaCl2) for crosslinking and studied ROS-responsive degradation and ion release.

Main Results:

  • ipPZCHs demonstrated significant antimicrobial activity against bone infections.
  • The hydrogels exhibited ROS-responsive disintegration, releasing antimicrobial zinc (Zn2+) and silver (Ag+) ions.
  • Degradation of ipPZCHs facilitated bone ingrowth, while released PC enhanced immunomodulatory and osteoinductive properties.

Conclusions:

  • The developed ipPZCHs offer a programmable and self-adaptive approach for infected bone repair.
  • The synergistic action of antimicrobial ion release, ROS-responsive degradation, and enhanced osteogenesis promotes effective bone healing.
  • This strategy holds promise for treating challenging bone infections and defects.