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Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Stringent Response in E. coli01:23

Stringent Response in E. coli

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Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
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Inducible Operons: lac Operon01:25

Inducible Operons: lac Operon

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The lac operon in Escherichia coli is a model for understanding inducible gene regulation and metabolic flexibility. It integrates local control by lactose and global regulation through catabolite repression, enabling E. coli to preferentially metabolize glucose when available and switch to lactose utilization when glucose is scarce.Structure and Function of the lac OperonThe lac operon contains three structural genes: lacZ (β-galactosidase), lacY (lactose permease), and lacA...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Updated: Jul 12, 2025

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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How Does Nutrition Affect the Epigenetic Changes in Dairy Cows?

Ana Lesta1, Pablo Jesús Marín-García2, Lola Llobat1

  • 1MMOPS Research Group, Departamento Producción y Sanidad Animal, Salud Pública y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain.

Animals : an Open Access Journal From MDPI
|October 27, 2023
PubMed
Summary

Optimizing dairy cow nutrition impacts epigenetic modifications, influencing gene expression, health, and milk production. Key nutrients like methionine and choline can alter DNA methylation for improved productivity.

Keywords:
DNA methylationcowepigenetic changeshistone deacetylationmiRNAmilk production

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Area of Science:

  • Animal Science
  • Epigenetics
  • Nutritional Biochemistry

Background:

  • Dairy cow health and productivity depend on balanced nutrition, with deficiencies causing metabolic issues and reduced yields.
  • Epigenetic modifications, including DNA methylation, are increasingly recognized as crucial mediators between diet and gene expression in livestock.
  • Understanding these nutritional epigenetics is vital for enhancing dairy cattle well-being and output.

Purpose of the Study:

  • To review how specific nutrients influence epigenetic modifications in dairy cows.
  • To analyze the impact of diet on gene expression, milk production, and milk composition through an epigenetic lens.
  • To highlight the potential of nutritional strategies for improving dairy cattle health and productivity via epigenetics.

Main Methods:

  • Literature review of studies investigating nutritional impacts on dairy cow epigenetics.
  • Analysis of dietary components (methionine, lysine, choline, folate) and their role in DNA methylation.
  • Examination of histone modifications and microRNAs as epigenetic regulators influenced by nutrition.

Main Results:

  • Dietary factors significantly affect DNA methylation patterns in dairy cows, influencing critical gene expression.
  • Specific nutrients like methionine, lysine, choline, and folate are identified as key modulators of these epigenetic changes.
  • Histone modifications and microRNAs also play roles in nutrient-mediated gene regulation in dairy cattle.

Conclusions:

  • Nutrition is a powerful tool for modulating epigenetic regulation in dairy cows, impacting health and productivity.
  • Optimizing dietary nutrient profiles can promote beneficial epigenetic modifications, leading to improved milk yield and composition.
  • Targeting nutritional epigenetics offers a promising avenue for sustainable and efficient dairy farming practices.