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Updated: Jul 12, 2025
05:21
Establishment of A Mouse Model of Aqueous Deficiency Dry Eye
Published on: November 1, 2024
603
Relationship between Dry Eye Disease and Dyslipidemia: A Systematic Review
Tzu-Hao Wang1,2, Yuan-Jen Tsai3, Yuan-Hung Wang4,5
1Division of General Medicine, Department of Medical Education, Shuang Ho Hospital, New Taipei City 23561, Taiwan.
Journal of Clinical Medicine
|October 28, 2023
Summary
Dyslipidemia is linked to dry eye disease (DED), especially in women. While most lipid profiles show no significant difference, the association between dyslipidemia and DED is statistically significant.
Area of Science:
- Ophthalmology
- Cardiovascular Health
- Metabolic Disorders
Background:
- Dry eye disease (DED) prevalence is potentially linked to dyslipidemia.
- The causal relationship between dyslipidemia and DED development requires further investigation.
Purpose of the Study:
- To systematically review and quantitatively analyze the association between dyslipidemia and DED.
- To clarify the role of lipid profile parameters in DED pathogenesis.
Main Methods:
- Systematic literature search conducted across major databases (PubMed, Embase, Cochrane Library, Web of Science, Google Scholar).
- Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
- Inclusion of six relevant studies for quantitative analysis.
Main Results:
- A significant association between dyslipidemia and DED was reported in most studies, particularly in female populations.
- Quantitative analysis showed statistically significant differences in total cholesterol and high-density lipoprotein cholesterol in only two studies.
- The majority of lipid profile parameters did not exhibit statistically significant differences between individuals with and without DED.
Conclusions:
- Despite no significant differences in most lipid parameters, a statistically significant association exists between dyslipidemia and DED.
- Further research is warranted to elucidate the precise mechanisms linking dyslipidemia to DED.
Keywords:
dry eyedry eye diseasedry eye syndromedyslipidemiahypercholesterolemiahyperlipidemiahypertriglyceridemiasystematic diseaseMore Related Videos
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