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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Functions of the Skeletal System01:22

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Bone Material Properties in Bone Diseases Affecting Children.

Adalbert Raimann1,2, Barbara M Misof2,3, Peter Fratzl4

  • 1Department of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Vienna, Austria.

Current Osteoporosis Reports
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Metabolic and genetic bone disorders impact bone quality and structure in children. Skeletal growth complicates interpretation of bone tissue findings in these pediatric patients.

Keywords:
Bone materialJuvenile boneMatrix mineralizationMetabolic bone disordersRare bone diseases

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Area of Science:

  • Pediatric Endocrinology
  • Bone Biology
  • Skeletal Dysplasias

Background:

  • Metabolic and genetic bone disorders affect bone mass, mineralization, matrix organization, and porosity.
  • Juvenile bone quality is significantly influenced by skeletal growth processes.
  • Understanding these factors is crucial for diagnosing and managing pediatric bone diseases.

Purpose of the Study:

  • To summarize the complex interplay between bone modeling and remodeling during skeletal growth.
  • To highlight the intricate bone tissue characteristics in children with metabolic and genetic bone disorders.
  • To alert clinicians to the challenges in interpreting bone findings in pediatric patients.

Main Methods:

  • Review of cellular events and tissue characteristics during linear skeletal growth.
  • Analysis of bone biopsy studies in children with various bone disorders.
  • Comparison of bone alterations in conditions with high, low, or normal mineral content.

Main Results:

  • Skeletal growth involves distinct cellular events and tissue organization (cartilage, woven bone, lamellar bone).
  • Disease-specific alterations in bone matrix mineralization and organization are observed.
  • Growth spurts or retardation can amplify or mask underlying disease-related bone changes.

Conclusions:

  • Bone modeling and remodeling during growth are complex and disease-dependent.
  • Interpreting bone tissue findings in children with metabolic or genetic disorders requires careful consideration of growth influences.
  • Accurate assessment of pediatric bone disorders necessitates understanding the interaction between disease and skeletal maturation.