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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Updated: Jul 12, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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Decoding aging-dependent regenerative decline across tissues at single-cell resolution.

Yusheng Cai1, Muzhao Xiong2, Zijuan Xin1

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.

Cell Stem Cell
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Aging significantly impairs tissue regeneration by affecting stem cell mobility and blood vessel formation. A specific macrophage type, Arg1+, plays a key role in this age-related decline, offering potential therapeutic targets.

Keywords:
Arg1(+) macrophageagingangiogenesisregenerationsingle-cell atlasstem cell mobilitytissue repair

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Area of Science:

  • Regenerative Medicine
  • Aging Biology
  • Immunology

Background:

  • Tissue regeneration capacity varies across the body and declines with age.
  • Understanding the molecular basis of age-related regenerative decline is crucial for developing interventions.

Purpose of the Study:

  • To comprehensively analyze single-cell transcriptomes during regeneration in young versus aged mice.
  • To identify cellular and molecular mechanisms underlying impaired regeneration in aged tissues.

Main Methods:

  • Single-cell transcriptome analysis of eight tissues from young and aged mice.
  • Application of diverse analytical models to study tissue regeneration dynamics.

Main Results:

  • Identified compromised stem cell mobility and inadequate angiogenesis as key factors in age-associated regenerative decline.
  • Discovered a subset of Arg1+ macrophages that are activated in young but suppressed in aged regenerating tissues.
  • Revealed disparities in age-related immune responses during regeneration.

Conclusions:

  • Aging impairs regeneration through specific cellular deficits, including stem cell function and vascularization.
  • Arg1+ macrophages represent a critical immune component whose dysregulation contributes to reduced regenerative capacity in aging.
  • This study provides a valuable single-cell resource for future therapeutic strategies to enhance regeneration in older individuals.