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Meta-analysis of the Relationship between Type 2 Diabetes Mellitus and Renal Cancer Risk

Yingxin Wang1, Ying Cao1, Chenchen Zhu1

  • 1Department of Ultrasound, The First Affiliated Hospital of Xinjiang Medical University, 830054, Xinjiang, People's Republic of China.

Endocrine, Metabolic & Immune Disorders Drug Targets
|November 3, 2023
PubMed
Abstract

Insights

Type 2 diabetes significantly elevates the risk of developing renal cancer. This meta-analysis confirms that individuals with type 2 diabetes have a 1.55 times higher risk of renal cancer compared to those without the condition.

Area of Science:

  • Nephrology
  • Endocrinology
  • Oncology

Background:

  • Type 2 diabetes mellitus (T2DM) is a global health concern with numerous complications.
  • Emerging evidence suggests a potential link between T2DM and increased cancer risk, including renal cancer.
  • Understanding this association is crucial for patient management and public health strategies.

Purpose of the Study:

  • To investigate the association between type 2 diabetes mellitus and the risk of renal cancer.
  • To quantify the risk of renal cancer in patients with T2DM through a meta-analysis.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, Embase, Web of Science, CBM, CNKI, Wanfang) from 2000 to 2022.
  • Included studies were cohort studies, independently screened and data extracted by two authors.
  • Meta-analysis was performed using Stata 12.0, calculating Risk Ratios (RR) with 95% Confidence Intervals (CI), and subgroup analyses were conducted.

Main Results:

  • Ten cohort studies were included in the meta-analysis.
  • Type 2 diabetes was associated with a significantly increased risk of renal cancer (RR = 1.57, 95% CI: 1.36–1.82, P<0.05).
  • The risk was consistently elevated in both men (RR = 1.49) and women (RR = 1.60), indicating T2DM is a risk factor for renal cancer.

Conclusions:

  • Type 2 diabetes mellitus is a significant risk factor for developing renal cell carcinoma.
  • Further multi-center studies with larger sample sizes are recommended, considering factors like diabetes type, population source, and treatment.
  • The specific mechanisms underlying this association and the impact of T2DM on renal cancer mortality require further investigation.
Keywords:
Diabetescohort studyconfidence intervalshypoglycemic drugsmortality.renal cancerrenal cell carcinoma

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