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[Apneic laryngeal chemoreflex and naloxone]
Revista Espanola De Fisiologia
|September 1, 1986
Summary
The canine apneic laryngeal chemoreflex (QRL) and mechanical laryngeal reflex (MRL) both cause apnea and bradycardia. Naloxone suggests endogenous opioids in the respiratory center inhibit these reflexes.
Area of Science:
- Respiratory Physiology
- Neuroscience
- Cardiovascular Regulation
Context:
- The laryngeal chemoreflex (QRL) and mechanical laryngeal reflex (MRL) are vital protective mechanisms.
- These reflexes involve complex neural pathways influencing breathing and heart rate.
Purpose:
- To compare the effects of QRL and MRL in dogs.
- To investigate the role of endogenous opioids in modulating these laryngeal reflexes.
Summary:
- Both QRL (water on vocal cords) and MRL (mechanical stimulation) in dogs induce apnea, bradycardia, hypotension, and glottic constriction.
- Apnea is more pronounced in QRL, while bradycardia is more intense in MRL.
- Naloxone administration significantly reduced all components of the response, indicating opioid involvement.
Impact:
- Findings suggest endogenous opioids within the respiratory center play a key inhibitory role in laryngeal reflexes.
- This research provides insights into the neurochemical control of airway protection.
- Understanding these mechanisms can inform clinical interventions for respiratory and cardiovascular events.